Pharmacology Rotigotine

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all affinities listed assayed using human materials except α2b-adrenergic done ng 108–15 cells. rotigotine behaves partial or full agonist (depending on assay) @ dopamine receptors listed, antagonist @ α2b-adrenergic receptor, , partial agonist @ 5-ht1a receptor. though has affinity large number of sites shown above, @ clinical doses rotigotine behaves selective d1-like (d1, d5) , d2-like (d2, d3, d4) receptor agonist, α2b-adrenergic , 5-ht1a activity possibly having minor relevance.








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