Relation to secondary and tertiary structure Protein primary structure

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the primary structure of biological polymer large extent determines three-dimensional shape (tertiary structure). protein sequence can used predict local features, such segments of secondary structure, or trans-membrane regions. however, complexity of protein folding prohibits predicting tertiary structure of protein sequence alone. knowing structure of similar homologous sequence (for example member of same protein family) allows highly accurate prediction of tertiary structure homology modeling. if full-length protein sequence available, possible estimate general biophysical properties, such isoelectric point.


sequence families determined sequence clustering, , structural genomics projects aim produce set of representative structures cover sequence space of possible non-redundant sequences.







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