Medical uses Dimercaptosuccinic acid

-


dimercaptosuccinic acid indicated treatment of lead poisoning in children blood level measured above 45 µg/dl. use of dmsa not approved prevention of lead poisoning in anticipation of exposure in known lead contaminated environments. elimination half-life 2.5–3.5 hours. dmsa can cross blood–brain barrier of mice, not of humans, limiting use extracting heavy metals parts of body other central nervous system.


dmsa facilitates urinary excretion of lead, , sufficiently aggressive treatment, can reduce lead content in brain. dmsa increases urinary excretion of copper , zinc. dmsa improved cognitive function in rats had been exposed lead, reduced cognitive function in rats had not been exposed lead.


the relative activities of series of novel monoalkyl esters of meso-2,3-dimercaptosuccinic acid (miadmsa) have been examined agents mobilization of cadmium, lead , arsenic owing ability of these monoesters cross cell membranes. monoesters found more effective parent compound dmsa. complexes (monoesters of dmsa) seem penetrate cells (not possible in case of dmsa), helps in targeting intracellular sites in body , aids in removal of toxic metal ions in cytosol , organelles inside cell.








Comments

Post a Comment

Popular posts from this blog

The battle for tallest status IDS Center

-
the crystal court ids tower ground the owners of capella tower (formerly first bank place) , architects behind design stated rose 774 feet (236 m) tall upon completion in 1992. however, height had been increased due engineering need, according tom o mara, 1 of construction managers @ time of capella tower construction. there ventilation ducts near roof required 14 more inches (36 cm) of height. construction team added 10 inches (25 cm) that, bringing building total of 776 feet 0 inches (236.52 m). in years following completion, actual height became known published in almanacs , other listings of building height. owners of capella tower hesitant claim building taller ids, , deferred honor more well-known structure. area journalists reported on sale of ids center john buck company in 2004 , death of designer philip johnson in 2005, came face-to-face fact roof of tower 1 foot lower neighbor. emporis.com restored ids center first-place status in city in fe...
Read more

Discography Butterfingers (Malaysian band)

-
1 discography 1.1 1994 – 2 tracks untitled recording (demo) 1.2 1995 – 12 goats, 6 oranges , 2 angels (demo) 1.3 1996 – butter couldn t melt (demo) 1.4 1996 – dragon (demo) 1.5 1996 – 1.2 milligrams (butterworld/emi) 1.6 1997 – butter worth pushful (butterworld/emi) 1.7 1999 – transcendence (butterworld/emi) 1.8 2000 – butter late never (unreleased tracks, live , rarities) (butterworld/emi) 1.9 2001 – malayneum (butterworld/emi) 1.10 2003 – best yet come 1994-20xx (butterworld/emi) 1.11 2005 – selamat tinggal dunia (butterworld/emi) 1.12 2008 – kembali (butterworld) 1.13 vcd 1.14 special release/live album 1.15 music videos 1.16 hit songs discography 1994 – 2 tracks untitled recording (demo) 1. girl friday 2. when re addicted (later renamed nicc o tynne ) 1995 – 12 goats, 6 oranges , 2 angels (demo) 1. wet blanket 2. ginseng 3. kindergarten (later renamed hatemaster ) 4. when re addicted (later renamed nicc o tynne ) 5. mystery 6. gum 7. spoilt (later renamed spoilt (in end) ) 1996...
Read more

Timeline Korean DMZ Conflict (1966–1969)

-
1 timeline 1.1 1966 1.2 1967 1.3 1968 1.4 1969 timeline 1966 2 november: 2nd infantry division (2id) patrol (1st battalion, 23rd infantry regiment) ambushed south of dmz. 6 u.s. kia, 1 katusa kia, 1 u.s. wia; unknown kpa losses. private ernest reynolds posthumously awarded silver star actions during ambush. roka patrol ambushed same night. 2 rok kia. 1967 12 february: 2id patrol (3–23 infantry) ambushed south of dmz. 1 u.s. kia; unknown kpa losses. 5 april: 2id guard post engaged kpa infiltrators south of dmz. no u.s. losses; 5 kpa kia. 29 april: 2id patrol ambushed kpa infiltrators south of dmz. no u.s. losses; 1 kpa kia, 1 kpa wia, 1 kpa captured. 22 may: 2id barracks (1–23 infantry) demolished daylight explosion south of dmz. 2 u.s. kia, 17 u.s. wia. 16 july: 2id barrier position #32 overrun. 3 u.s. kia (2-23 infantry), 1 katusa wia. 10 august: 7id construction team (b company 2/31st inf. 7th id) ambushed south of dmz in daylight. 3 u.s. kia, sixteen u.s. wia, 1 wia later died of wo...
Read more